石宛鑫,李娜,隋满姝
SHI Wan-xin,LI Na,SUI Man-shu

• 1:哈尔滨医科大学附属第一医院肾内科

摘要(Abstract)：

叉头框转录因子O(forkhead box O,FoxO)是体内众多重要信号传导通路中的关键调控因子之一。FoxO作为调节细胞增殖、氧化应激、细胞凋亡、细胞自噬、代谢和免疫反应等多种细胞功能的转录因子,主要通过转录和传导各种生长因子及细胞因子信号发挥其生物学功能,其中FoxO1、FoxO3a在肾脏病发病机制中发挥重要作用。本文就FoxO的结构、功能及其在肾脏疾病中作用的研究进展作一综述。
Forkhead box O(FoxO)is one of the key regulatory factors in vivo in many important signal transduction pathways.Being a transcription factor for regulating cell proliferation,oxidative stress responses,apoptosis,autophagy,metabolism and immune reaction,FoxO plays its biological function by the transcription and transmission of growth factors and cytokines signaling,in which FoxO1 and FoxO3 aplay an important role in the pathogenesis of kidney diseases.This paper reviews the research progress of the structure and function of FoxO,as well as its role in the treatment of kidney diseases.

关键词(KeyWords)： 肾脏病;叉头框转录因子O1;叉头框转录因子O3a
Kidney diseases;forkhead box O1;forkhead box O3a

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省自然科学基金(81370831)

作者(Author): 石宛鑫,李娜,隋满姝
SHI Wan-xin,LI Na,SUI Man-shu

参考文献(References)：

• [1]KOUSTENI S.FoxO1:a molecule for all seasons[J].J Bone Miner Res,2011,26(5):912-917.
• [2]鲁旭亮.糖尿病肾病患者血清脂联素和血管内皮生长因子水平与氧化应激的相关性[J].中华实用诊断与治疗杂志,2013,27(2):147-149.
• [3]KATO M,YUAN H,XU Z G,et al.Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction:a novel mechanism related to diabetic kidney disease[J].J Am Soc Nephrol,2006,17(12):3323-3335.
• [4]WANG X,MENG L,ZHAO L,et al.Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FoxO3apathway[J].Diabetes Res Clin Pract,2016,126:172-181.
• [5]QIN G,ZHOU Y,GUO F,et al.Overexpression of the FoxO1ameliorates mesangial cell dysfunction in male diabetic rats[J].Mol Endocrinol,2015,29(7):1080-1091.
• [6]DAS F,GHOSH-CHOUDHURY N,DEY N,et al.High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression[J].J Biol Chem,2014,289(47):32703-32716.
• [7]GUO F,WANG Q,ZHOU Y,et al.Lentiviral vector-mediated FoxO1 overexpression inhibits extracellular matrix protein secretion under high glucose conditions in mesangial cells[J].J Cell Biochem,2016,117(1):74-83.
• [8]LIU F,MA X J,WANG Q Z,et al.The effect of FoxO1on the proliferation of rat mesangial cells under high glucose conditions[J].Nephrol Dial Transplant,2014,29(10):1879-1887.
• [9]DU M,WANG Q,LI W,et al.Overexpression of FoxO1ameliorates the podocyte epithelial-mesenchymal transition induced by high glucose in vitro and in vivo[J].Biochem Biophys Res Commun,2016,471(4):416-422.
• [10]GUO F,ZHANG Y,WANG Q,et al.Effects of FoxO1on podocyte injury in diabetic rats[J].Biochem Biophys Res Commun,2015,466(2):260-266.
• [11]麦地努尔·阿不力米提,桑晓红.狼疮性肾炎患者预后影响因素分析[J].中华实用诊断与治疗杂志,2017,31(2):139-141.
• [12]KUO C C,LIN S C.Altered FoxO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients[J].Mol Med,2007,13(11/12):561-566.
• [13]FENG X J,WU C,YANG G F,et al.TLR2plays a critical role in HMGB1-induced glomeruli cell proliferation through the FoxO1signaling pathway in lupus nephritis[J].J Interferon Cytokine Res,2016,36(4):258-266.
• [14]NHO R S,HERGERT P.FoxO3aand disease progression[J].World J Biol Chem,2014,5(3):346-354.
• [15]LU M,XU W,GAO B,et al.Blunting autoantigen-induced FoxO3aprotein phosphorylation and degradation is a novel pathway of glucocorticoids for the treatment of systemic lupus erythematosus[J].J Biol Chem,2016,291(38):19900-19912.
• [16]LI Y,ZHONG D,LEI L,et al.Propofol prevents renal ischemia-reperfusion injury via inhibiting the oxidative stress pathways[J].Cell Physiol Biochem,2015,37(1):14-26.
• [17]WANG Y,MU Y,ZHOU X,et al.SIRT2-mediated FoxO3a deacetylation drives its nuclear translocation triggering FasLinduced cell apoptosis during renal ischemia reperfusion[J].Apoptosis,2017,22(4):519-530.
• [18]WU H,HUANG T,YING L,et al.MiR-155is involved in renal ischemia-reperfusion injury via direct targeting of FoxO3a and regulating renal tubular cell pyroptosis[J].Cell Physiol Biochem,2016,40(6):1692-1705.
• [19]YOON H E,KIM S J,KIM S J,et al.Tempol attenuates renal fibrosis in mice with unilateral ureteral obstruction:the role of PI3K-Akt-FoxO3asignaling[J].J Korean Med Sci,2014,29(2):230-237.
• [20]YANG C,CAO Y,ZHANG Y,et al.Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3apathway[J].J Transl Med,2015,13(1):1-10.
• [21]WANG B,DING W,ZHANG M,et al.Role of FoxO1in aldosterone-induced autophagy:a compensatory protective mechanism related to podocyte injury[J].Oncotarget,2016,7(29):45331-45351.