经腋窝入路单孔腔镜手术治疗甲状腺肿瘤的疗效及安全性Curative effect and safety of single-hole transaxillary endoscopic thyroidectomy in the treatment of thyroid tumor
戴经纬,齐向秀,冯丽,苏洋
DAI Jing-wei,QI Xiang-xiu,FENG Li,SU Yang
摘要(Abstract):
目的探讨经腋窝入路单孔腔镜手术治疗甲状腺肿瘤的疗效和安全性。方法 130例甲状腺肿瘤患者,随机分为观察组和对照组各65例,观察组采用经腋窝入路单孔腔镜手术,对照组采用传统甲状腺手术,比较2组手术时间、术中出血量、术后住院时间、术后24、48h视觉模拟量表评分及术后1个月并发症发生情况。结果观察组患者术中出血量[(23.09±10.20)mL]、术后住院时间[(4.33±1.24)d]、术后24、48h视觉模拟评分[(3.82±1.02)、(2.79±0.82)分]均低于对照组[(38.13±12.94)mL、(6.22±0.98)d、(5.42±1.44)分、(3.88±1.07)分](P<0.05),手术时间[(170.35±20.51)min]与对照组[(165.33±19.40)min]比较差异无统计学意义(P>0.05);术后1个月,观察组发生皮下气肿1例,低钙血症1例,甲状旁腺功能低下1例;对照组发生皮下气肿3例,喉返神经损伤1例,低钙血症4例,甲状旁腺功能低下4例;观察组术后1个月并发症发生率(4.6%)明显低于对照组(18.5%)(P<0.05)。结论经腋窝入路单孔腔镜手术在甲状腺肿瘤患者中的应用具有较高可行性,可减轻疼痛,加快康复,降低术后并发症发生率。
Objective To investigate the curative effect and safety of single-hole transaxillary endoscopic thyroidectomy in the treatment of thyroid tumor.Methods Totally 130 patients with thyroid tumor were randomly divided into observation group and control group,with 65 patients in each group.Observation group underwent single-hole transaxillary endoscopic thyroidectomy and control group underwent conventional open thyroidectomy.The operation lasting time,intraoperative blood loss,hospitalization stay,postoperative 24-and 48-h visual analogue score,and postoperative 1-month complication rate were compared between two groups.Results The intraoperative blood loss((23.09±10.20)mL)was significantly less,postoperative hospitalization stay((4.33±1.24)d)was significantly shorter,and postoperative 24-and 48-h visual analogue scores(3.82±1.02,2.79±0.82)were significantly lower in observation group than those in control group((38.13±12.94)mL,(6.22±0.98)d,5.42±1.44,3.88±1.07)(P<0.05),and there was no significant difference in the operation lasting time between observation group((170.35±20.51)min)and control group((165.33±19.40)min)(P>0.05).The complications in 1 month after operation included subcutaneous emphysema in 1 patient,hypocalcemia in 1 and hypoparathyroidism in 1 in observation group,while subcutaneous emphysema in 3 patients,recurrent laryngeal nerve injury in 1,hypocalcemia in 4,and hypoparathyroidism in 4 in control group.The postoperative 1-month complication rate was significantly lower in observation group(4.6%)than that in control group(18.5%)(P<0.05).Conclusion The single-hole transaxillary endoscopic thyroidectomy has agood feasibility,and it can promote the rehabilitation,relieve pain,and reduce the complication rate in the treatment of thyroid tumor.
关键词(KeyWords):
甲状腺肿瘤;腋窝;单孔腔镜手术;疼痛;并发症
Thyroid tumor;axillary;single-hole endoscopic thyroidectomy;pain;complications
基金项目(Foundation): 辽宁省科技厅科学技术计划项目(2013225049)
作者(Author):
戴经纬,齐向秀,冯丽,苏洋
DAI Jing-wei,QI Xiang-xiu,FENG Li,SU Yang
参考文献(References):
- [1]蒋圣早,彭云华,王文斌,等.分化型甲状腺癌手术方式42例分析[J].中国现代医生,2015,16(14):33-35.
- [2]GU T,JIANG B,WANG N,et al.New insight into ectopic thyroid glands between the neck and maxillofacial region from a42-case study[J].BMC Endocr Disord,2015,18(15):70-72.
- [3]王法,杨晓婧,娜迪热·铁列吾汗.超声造影定量分析技术在甲状腺结节诊断中价值[J].中华实用诊断与治疗杂志,2016,30(3):239-241.
- [4]霍晓明,张红,李逢生.超声造影与常规超声诊断甲状腺乳头状癌价值[J].中华实用诊断与治疗杂志,2016,30(10):1019-1021.
- [5]王勇,赵群仔,燕海潮,等.三维腔镜胸前入路甲状腺癌手术32例临床分析[J].中华外科杂志,2015,53(3):176-178.
- [6]JANTHARAPATTANA K,MAETHASITH J.Transaxillary gasless endoscopic thyroidectomy versus conventional open thyroidectomy:a randomized study[J].Eur Arch Otorhinolaryngol,2017,274(1):495-500.
- [7]吴志红,葛明华,骆剑明.甲状腺良性疾病手术中保留甲状腺后被膜对保护甲状旁腺及喉返神经的效果观察[J].浙江创伤外科,2015,20(5):1010-1012.
- [8]杜军威,邱新光.分化型甲状腺癌术后复发研究新进展[J].医药论坛杂志,2014,35(1):141-143.
- [9]洪维聪,郭宇.开放甲状腺手术中应用超声刀与传统方法的对比研究[J].中华全科医学,2015,13(3):498-500.
- [10]KANG J B,KIM E Y,PARK Y L,et al.A comparison of postoperative pain after conventional open thyroidectomy and single-incision,gasless,endoscopic transaxillary thyroidectomy:a single institute prospective study[J].Ann Surg Treat Res,2017,92(1):9-14.
- [11]程国凌.应用小切口行甲状腺瘤切除术66例效果分析[J].医药论坛杂志,2014,35(9):130-131.
- [12]罗义,李阳敏,魏成刚,等.经腋窝入路单孔腔镜手术对甲状腺肿瘤患者应激代谢的影响[J].浙江临床医学,2017,19(1):32-33.
- [13]ARAI N,INABA M,ICHIJYO T,et al.Thyrotropinproducing pituitary adenoma simultaneously existing with Gravesdisease:a case report[J].J Med Case Rep,2017,11(1):9-13.
- [14]LEE S H,PARK J S,LEE S,et al.Parasellar extension grades and surgical extent in endoscopic endonasal transsphenoidal surgery for pituitary adenomas:a single surgeons consecutive series with the aspects of reliability and clinical validity[J].J Korean Neurosurg Soc,2016,59(6):577-583.
- [15]ZAIDI N,BUCAK E,YAZICI P,et al.The feasibility of indocyanine green fluorescence imaging for identifying and assessing the perfusion of parathyroid glands during total thyroidectomy[J].J Surg Oncol,2016,4(4):99-101.
- [16]FRANK E,PARK J,SIMENTAL A J,et al.Minimally invasive video-assisted thyroidectomy:almost a decade of experience at an academic center[J].Am Surg,2016,82(10):949-952.